Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

Polymeric nanostructures for drug delivery applications including smart hydrogels and stealth micelles have been developed to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation is to prepare and characterize novel nanoparticle-based colloidal products composed of biocompatible polymers to us...

Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir...

Polymeric micelles as drug delivery vehicles

Self-assembled PEG–carboxymethylcellulose nanoparticles/α-cyclodextrin hydrogels for injectable and thermosensitive drug delivery

Tianjin Key Laboratory of Pulp and Pa Technology, Tianjin 300457, China. E-m 60602226; Tel: +86-22-60602226 State Key Laboratory of Tree Genetics and Chinese Academy of Forestry, Beijing 10009 Jiangsu Province Biomass Energy and Ma Industry of Forest Products, CAF, Nanjing 2 State Key Laboratory of Pulp and Paper Technology, Guangzhou 510640, China † Electronic supplementary informa 10.1039/c6r...

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or ...